PTK2B-Polyclonal Antibodies

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PTK2B

Qty


Total
$220
Catalog #
A0074
Antibody Type
Polyclonal Antibody
Gene ID
2185
Swiss Prot
Q14289
Size
Species
Rabbit
Isotype
IgG
Purity
Affinity purification
Additional Information
ReactivityHuman
Tested applicationsWB IHC IF
Recommended DilutionWB 1:500 - 1:2000 IHC 1:50 - 1:200 IF 1:20 - 1:50
Calculated MW116kDa
Observed MWRefer to Figures
ImmunogenA synthetic peptide of human PTK2B
Storage BufferStore at 4℃. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Concentrationbq
SynonymPKB; PTK; CAKB; FAK2; PYK2; CADTK; FADK2; RAFTK;
Images
  • A0074: image 1

    Western blot analysis of extracts of Jurkat cell line, using PTK2B antibody.

Background

This gene encodes a cytoplasmic protein tyrosine kinase which is involved in calcium-induced regulation of ion channels and activation of the map kinase signaling pathway. The encoded protein may represent an important signaling intermediate between neuropeptide-activated receptors or neurotransmitters that increase calcium flux and the downstream signals that regulate neuronal activity. The encoded protein undergoes rapid tyrosine phosphorylation and activation in response to increases in the intracellular calcium concentration, nicotinic acetylcholine receptor activation, membrane depolarization, or protein kinase C activation. This protein has been shown to bind CRK-associated substrate, nephrocystin, GTPase regulator associated with FAK, and the SH2 domain of GRB2. The encoded protein is a member of the FAK subfamily of protein tyrosine kinases but lacks significant sequence similarity to kinases from other subfamilies. Four transcript variants encoding two different isoforms have been found for this gene.

Protocol

N/A

MSDS
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