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Reactivity | Human Mouse Rat |
Tested applications | WB IHC IF |
Recommended Dilution | WB 1:500 - 1:2000 IHC 1:50 - 1:200 IF 1:50 - 1:200 |
Calculated MW | 49kDa |
Observed MW | Refer to Figures |
Immunogen | Recombinant protein of human PTPN2 |
Storage Buffer | Store at -20℃. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
Concentration | o |
Synonym | PTN2; PTPT; TCPTP; TC-PTP; TCELLPTP; |
Western blot analysis of extracts of various cell lines, using PTPN2 antibody.
Immunohistochemistry of paraffin-embedded rat heart using PTPN2 antibody at dilution of 1:100 (400x lens).
Immunofluorescence analysis of MCF7 cell using PTPN2 antibody. Blue: DAPI for nuclear staining.
Immunofluorescence analysis of MCF-7 cell using PTPN2 antibody. Blue: DAPI for nuclear staining.
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. Members of the PTP family share a highly conserved catalytic motif, which is essential for the catalytic activity. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. Epidermal growth factor receptor and the adaptor protein Shc were reported to be substrates of this PTP, which suggested the roles in growth factor mediated cell signaling. Multiple alternatively spliced transcript variants encoding different isoforms have been found. Two highly related but distinctly processed pseudogenes that localize to chromosomes 1 and 13, respectively, have been reported. [provided by RefSeq, May 2011]
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