Phospho-MAP2K1/MAP2K2-S217/S221-Tag and Loading control Antibodies

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Phospho-MAP2K1/MAP2K2-S217/S221

Qty


Total
$300
Catalog #
AP0209
Antibody Type
Polyclonal Antibody
Gene ID
5604/ 5605
Swiss Prot
Q02750/P36507
Size
Species
Rabbit
Isotype
IgG
Purity
Affinity purification
Additional Information
ReactivityHuman Mouse Rat
Tested applicationsWB IHC
Recommended DilutionWB 1:500 - 1:1000 IHC 1:50 - 1:100
Calculated MW45kDa
Observed MWRefer to Figures
ImmunogenA phospho specific peptide corresponding to residues surrounding serine 217/221 of human MAP2K1/MAP2K2.
Storage BufferStore at -20℃. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
SynonymCFC3/CFC4; MEK1/MEK2; MKK1/MKK2; MAPKK1/MAPKK2; PRKMK1/PRKMK2;
Images
  • AP0209: image 1

    Western blot analysis of extracts from Hela cell untreated or treated with UV using Phospho-MAP2K1/MAP2K2-S217/S221 antibody

Background

The protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase is known to play a critical role in mitogen growth factor signal transduction. It phosphorylates and thus activates MAPK1/ERK2 and MAPK2/ERK3. The activation of this kinase itself is dependent on the Ser/Thr phosphorylation by MAP kinase kinase kinases. Mutations in this gene cause cardiofaciocutaneous syndrome (CFC syndrome), a disease characterized by heart defects, mental retardation, and distinctive facial features similar to those found in Noonan syndrome. The inhibition or degradation of this kinase is also found to be involved in the pathogenesis of Yersinia and anthrax. A pseudogene, which is located on chromosome 7, has been identified for this gene.

Protocol

N/A

MSDS
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