RASGRP1-Monoclonal Antibodies

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RASGRP1

Qty


Total
$220
Catalog #
A10495
Antibody Type
Polyclonal Antibody
Gene ID
10125
Swiss Prot
O95267
Size
Species
Rabbit
Isotype
IgG
Purity
Affinity purification
Additional Information
ReactivityHuman
Tested applicationsWB
Recommended DilutionWB 1:1000 - 1:2000
Calculated MW90kDa
Observed MWRefer to figures
ImmunogenRecombinant protein of human RASGRP1
Storage BufferStore at -20℃. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
SynonymV; RASGRP; hRasGRP1; CALDAG-GEFI; CALDAG-GEFII;
Images
  • A10495: image 1

    Western blot analysis of extracts of various cells, using RASGRP1 antibody.

Background

This gene is a member of a family of genes characterized by the presence of a Ras superfamily guanine nucleotide exchange factor (GEF) domain. It functions as a diacylglycerol (DAG)-regulated nucleotide exchange factor specifically activating Ras through the exchange of bound GDP for GTP. It activates the Erk/MAP kinase cascade and regulates T-cells and B-cells development, homeostasis and differentiation. Alternatively spliced transcript variants encoding different isoforms have been identified. Altered expression of the different isoforms of this protein may be a cause of susceptibility to systemic lupus erythematosus (SLE).

Protocol

N/A

MSDS
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