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| Reactivity | Human |
| Tested applications | WB IHC FC |
| Recommended Dilution | WB 1:500 - 1:1000 IHC 1:50- 1:100 FC 1:20- 1:50 |
| Calculated MW | 106kDa |
| Observed MW | Refer to Figures |
| Immunogen | A synthetic Peptide of human RB |
| Storage Buffer | Store at 4℃. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Synonym | RB1; pRb; OSRC; pp110; p105-Rb; PPP1R130 |
The protein encoded by this gene is a negative regulator of the cell cycle and was the first tumor suppressor gene found. The encoded protein also stabilizes constitutive heterochromatin to maintain the overall chromatin structure. The active, hypophosphorylated form of the protein binds transcription factor E2F1. Defects in this gene are a cause of childhood cancer retinoblastoma (RB), bladder cancer, and osteogenic sarcoma.
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