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Reactivity | Human Mouse |
Tested applications | WB IHC ICC IF IP FC |
Recommended Dilution | WB 1:500 - 1:2000 IHC 1:50 - 1:200 ICC 1:50 - 1:200 IF 1:50 - 1:100 IP 1:20 - 1:50 FC 1:20 - 1:50 |
Calculated MW | 65 kDa |
Observed MW | Refer to figures |
Immunogen | Recombinant protein of human RELA |
Storage Buffer | Store at -20℃. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
Synonym | p65; NFKB3; |
Immunohistochemistry of paraffin-embedded mouse lung using RELA antibody at dilution of 1:100 (40x lens).
Immunohistochemistry of paraffin-embedded human mammary cancer using RELA antibody at dilution of 1:100 (40x lens).
Immunohistochemistry of paraffin-embedded human lung using RELA antibody at dilution of 1:100 (40x lens).
Immunofluorescence
NF-kappa-B is a ubiquitous transcription factor involved in several biological processes. It is held in the cytoplasm in an inactive state by specific inhibitors. Upon degradation of the inhibitor, NF-kappa-B moves to the nucleus and activates transcription of specific genes. NF-kappa-B is composed of NFKB1 or NFKB2 bound to either REL, RELA, or RELB. The most abundant form of NF-kappa-B is NFKB1 complexed with the product of this gene, RELA. Four transcript variants encoding different isoforms have been found for this gene.
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