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| Reactivity | Human Mouse Rat |
| Tested applications | WB IHC ICC IP FC |
| Recommended Dilution | WB 1:500 - 1:2000 IHC 1:50 - 1:100 ICC 1:50 - 1:200 IP 1:20 - 1:50 FC 1:20 - 1:50 |
| Calculated MW | 83kDa |
| Observed MW | Refer to Figures |
| Immunogen | A synthetic peptide of human RPS6KA1 |
| Storage Buffer | Store at -20℃. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Concentration | fpq |
| Synonym | HU-1;MAPKAPK1A;RSK;RSK1;Ribosomal protein S6 kinase alpha-1 antibody; Ribosomal S6 kinase 1 antibody; |
RSK 1 (p90-RSK 1) is a member of a family of 90 kDa ribosomal protein S6 kinases, which includes RSK 1, RSK 2 and RSK 3. These are broadly expressed serine/threonine protein kinases activated in response to mitogenic stimuli, including extracellular signal-regulated protein kinases Erk1 and Erk2. p90-RSK 1 is activated by MAPK in vitro and in vivo via phosphorylation. Active RSKs appear to play a major role in transcriptional regulation by translocating to the nucleus and phosphorylating c-Fos and CREB.
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