|Reactivity||Human Mouse Rat|
|Tested applications||WB IHC ICC IP FC|
|Recommended Dilution||WB 1:500 - 1:2000
IHC 1:50 - 1:100
ICC 1:50 - 1:200
IP 1:20 - 1:50
FC 1:20 - 1:50|
|Observed MW||Refer to Figures|
|Immunogen||A synthetic peptide of human RPS6KA1|
|Storage Buffer||Store at -20℃. Avoid freeze / thaw cycles.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.|
|Synonym||HU-1;MAPKAPK1A;RSK;RSK1;Ribosomal protein S6 kinase alpha-1 antibody; Ribosomal S6 kinase 1 antibody;|
RSK 1 (p90-RSK 1) is a member of a family of 90 kDa ribosomal protein S6 kinases, which includes RSK 1, RSK 2 and RSK 3. These are broadly expressed serine/threonine protein kinases activated in response to mitogenic stimuli, including extracellular signal-regulated protein kinases Erk1 and Erk2. p90-RSK 1 is activated by MAPK in vitro and in vivo via phosphorylation. Active RSKs appear to play a major role in transcriptional regulation by translocating to the nucleus and phosphorylating c-Fos and CREB.
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