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| Reactivity | Human |
| Tested applications | WB |
| Recommended Dilution | WB 1:200 - 1:2000 |
| Calculated MW | 57kDa |
| Observed MW | Refer to Figures |
| Immunogen | Recombinant protein of human SESN3 |
| Storage Buffer | Store at -20℃. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Synonym | SEST3; |
This gene encodes a member of the sestrin family of stress-induced proteins. The encoded protein reduces the levels of intracellular reactive oxygen species induced by activated Ras downstream of RAC-alpha serine/threonine-protein kinase (Akt) and FoxO transcription factor. The protein is required for normal regulation of blood glucose, insulin resistance and plays a role in lipid storage in obesity. Alternative splicing results in multiple transcript variants.
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