SHH-Polyclonal Antibodies

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SHH

Qty


Total
$220
Catalog #
A0095
Antibody Type
Polyclonal Antibody
Gene ID
6469
Swiss Prot
Q15465
Size
Species
Rabbit
Isotype
IgG
Purity
Affinity purification
Additional Information
ReactivityMouse
Tested applicationsWB
Recommended DilutionWB 1:200 - 1:2000
Calculated MW50kDa
Observed MWRefer to Figures
ImmunogenA synthetic peptide of human SHH
Storage BufferStore at 4℃. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Concentrationam
SynonymSHH;HHG1;HLP3;HPE3;MCOPCB5;SMMCI;TPT;TPTPS
Images
  • A0095: image 1

    Western blot analysis of extracts of mouse liver cell line, using SHH antibody.

Background

Hedgehog proteins (Hh) are secreted signaling proteins that play many roles during animal development. Aberrant Hh signaling activity can be associated with numerous birth defects and uncontrolled Hh pathway activation is linked to the development of several types of cancers (1-2). The three identified vertebrate Hh genes are Sonic (Shh), Indian (Ihh) and Desert (Dhh), all of which have distinct as well as overlapping roles (3-5). Hh proteins are synthesized as 45 kDa precursors that undergo auto-cleavage to generate a 19 kDa amino-terminal peptide (Hh-N) and a carboxy-terminal peptide (Hh-C). The amino-terminal peptide becomes covalently attached to a cholesterol molecule at its carboxy terminus and acetylated at its amino terminus. This doubly modified Hh-N peptide is released from cells and responsible for all known Hedgehog signaling activity (6).

Protocol

N/A

MSDS
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