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Reactivity | Human Mouse |
Tested applications | WB IHC |
Recommended Dilution | WB 1:500 - 1:2000 IHC 1:100 - 1:200 |
Calculated MW | 43kDa |
Observed MW | Refer to Figures |
Immunogen | A synthetic peptide of human SIRT3 |
Storage Buffer | Store at -20℃. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
Concentration | f |
Synonym | SIR2L3; |
Western blot analysis of extracts of various tissues, using SIRT3 antibody.
Immunohistochemistry of paraffin-embedded human prostate using SIRT3 antibody at dilution of 1:100 (40x lens).
Immunohistochemistry of paraffin-embedded human esophagus using SIRT3 antibody at dilution of 1:100 (40x lens).
Immunohistochemistry of paraffin-embedded human stomach using SIRT3 antibody at dilution of 1:100 (40x lens).
This gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class I of the sirtuin family. Two alternatively spliced transcript variants that encode different proteins have been described for this gene.
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