SLC2A4-Monoclonal Antibodies

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SLC2A4

Qty


Total
$380
Catalog #
A0071
Antibody Type
Monoclonal Antibody
Gene ID
6517
Swiss Prot
P14672
Size
Species
Mouse
Isotype
IgG
Purity
Affinity purification
Additional Information
ReactivityHuman Mouse Rat
Tested applicationsWB
Recommended DilutionWB 1:500 - 1:1000
Calculated MW56kDa
Observed MWRefer to Figures
ImmunogenRecombinant protein of human SLC2A4
Storage BufferStore at -20℃. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
SynonymSLC2A4;GLUT4;Solute carrier family 2;facilitated glucose transporter member 4;Glucose transporter type 4; insulin-responsive;
Images
  • A0071: image 1

    Western blot analysis of extracts of skeletal muscle and mouse heart, using SLC2A4 antibody.

Background

A group of related glucose transporters (Glut1-5 and 7) mediate the facilitated diffusion of glucose in nonepithelial mammalian tissues. Within insulin-responsive tissues such as muscle and fat, Glut1 contributes to basal glucose uptake while SLC2A4 is responsible for insulin-stimulated glucose transport (1-3). SLC2A4 is a 12-transmembrane domain protein that facilitates glucose transport in the direction of the glucose gradient. This transporter localizes to intracellular organelles (endosomes) in unstimulated cells and translocates to the cell surface following insulin stimulation (1,2,4). Translocation of SLC2A4 is dependent on Akt, which may act by phosphorylating AS160, a RabGAP protein involved in membrane trafficking (5).

Protocol

N/A

MSDS
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