SLC8A1-Methylated Antibodies

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SLC8A1

Qty


Total
$220
Catalog #
A1496
Antibody Type
Polyclonal Antibody
Gene ID
6546
Swiss Prot
P32418
Size
Species
Rabbit
Isotype
IgG
Purity
Affinity purification
Additional Information
ReactivityHuman Mouse Rat
Tested applicationsWB IHC FC
Recommended DilutionWB 1:200 - 1:500 IHC 1:50 - 1:100 FC 1:10 - 1:50
Calculated MW109kDa
Observed MWRefer to Figures
ImmunogenA synthetic peptide of human SLC8A1
Storage BufferStore at 4℃. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
SynonymSLC8A1;CNC; NCX1;
Images
  • A1496: image 1

    Western blot analysis of HL-60 cell and K562 cell lysate using SLC8A1 antibody.

Background

Sodium/calcium exchanger proteins are integral membrane proteins primarily seen in cardiac cells. In cardiac myocytes, the concentration of Ca2+ alternates between low levels during relaxation and high levels during contraction. The Na+/Ca2+ exchanger 1 (NCX1) protein mediates Ca2+ extrusion from cardiac cells during relaxation. Four NCX1 isoforms (NCX1.1, NCX1.3, NCX1.7 and NCX1.10) result from alternate splicing. NCX1 mRNA is present at high levels in the heart, with lower levels present in the brain. NCX2 is most abundantly expressed in brain, in contrast the the broader distribution of NCX1, which is also expressed in heart, kidney, lung, smooth and skeletal muscle. The difference in expression for the transporter subtypes is believed to reflect differences in their functional roles. Regulation mechanisms for these exchanger proteins have not been fully characterized.

Protocol

N/A

MSDS
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