|Reactivity||Human Mouse Rat|
|Recommended Dilution||WB 1:1000 - 1:4000|
|Observed MW||Refer to Figures|
|Immunogen||Recombinant protein of human SLC9A3R1|
|Storage Buffer||Store at -20℃. Avoid freeze / thaw cycles.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.|
|Synonym||EBP50;NHERF;NHERF-1;NHERF1;NPHLOP2;Regulatory cofactor of Na(+)/H(+) exchanger antibody;Sodium-hydrogen exchanger regulatory factor 1 antibody;Solute carrier family 9 isoform A3 regulatory factor 1 antibody;|
NHERF1 is a sodium/hydrogen exchanger regulatory cofactor. It interacts with and regulates various proteins including the cystic fibrosis transmembrane conductance regulator and G-protein coupled receptors such as the beta2-adrenergic receptor and the parathyroid hormone 1 receptor. NHERF1 also interacts with proteins that function as linkers between integral membrane and cytoskeletal proteins. It localizes to actin-rich structures including membrane ruffles, microvilli, and filopodia. Mutations in NHERF1 result in hypophosphatemic nephrolithiasis/osteoporosis type 2, and loss of heterozygosity of this protein is implicated in breast cancer.
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