|Reactivity||Human Mouse Rat|
|Tested applications||WB IHC ICC IP|
|Recommended Dilution||WB 1:500 - 1:1000
IHC 1:50 - 1:200
ICC 1:50 - 1:200
IP 1:20 - 1:100|
|Observed MW||Refer to Figures|
|Immunogen||A synthetic peptide of human SMAD3|
|Storage Buffer||Store at -20℃. Avoid freeze / thaw cycles.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.|
|Synonym||HSPC193; HsT17436; JV15-2; LDS1C; LDS3; MADH3;|
Smad proteins belong to a group of intracellular signal transducers and downstream effectors of TGF-β/BMP Signaling. The family consists of nine members that are highly conserved in the N- and C-terminal regions. Smad3 is a key component in intracellular signaling of transforming growth factor beta (TGF-β), an inhibitor for tumor cell proliferation. Smad3 is activated by activin/TGF-β receptors, which form a heteromeric complex with Smad4, translocating to the nucleus and regulating the expression of TGF- β target genes. Interaction of Smad3 with Akt, can initiate TGF- β induced apoptosis and cell cycle arrest. Smad3 expression may be critical in tumor suppression in early stages of gastric carcinogenesis.
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