SMNDC1-Polyclonal Antibodies

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SMNDC1

Qty


Total
$220
Catalog #
A0681
Antibody Type
Polyclonal Antibody
Gene ID
10285
Swiss Prot
O75940
Size
Species
Rabbit
Isotype
IgG
Purity
Affinity purification
Additional Information
ReactivityHuman Mouse Rat
Tested applicationsWB IHC
Recommended DilutionWB 1:500 - 1:2000 IHC 1:50 - 1:200
Calculated MW27kDa
Observed MWRefer to Figures
ImmunogenRecombinant protein of human SMNDC1
Storage BufferStore at -20℃. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Concentrationbj
SynonymSMNDC1;SMNR;SPF30 ;
Images
  • A0681: image 1

    Western blot analysis of 721-B cell lysate using SMNDC1 antibody.

Background

SPF30 (survival of motor neuron-related-splicing factor 30), also known as SMNDC1 (survival motor neuron domain containing 1) or SMNR (SMN-related protein), is an essential splicing factor required for spliceosome assembly that belongs to the SMN family. It contains one Tudor domain with significant similarity to SMN (Survival Motor Neuron) and is expressed in skeletal muscle, pancreas and heart, localizing to Cajal bodies and nuclear speckles. SPF30 plays an important role in spliceosome assembly and directly interacts with five U snRNPs. The loss of SPF30 causes spliceosome assembly to arrest at prespliceosomes (A complex). This supports a function for SPF30 in mediating the incorporation/recruitment of U4/U5/U6 tri-snRNP to the prespliceosome. In addition, the overexpression of SPF30 can lead to apoptosis.

Protocol

N/A

MSDS
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