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Reactivity | Human Mouse Rat |
Tested applications | WB IHC |
Recommended Dilution | WB 1:500 - 1:2000 IHC 1:50 - 1:100 |
Calculated MW | 24kDa |
Observed MW | Refer to figures |
Immunogen | A synthetic peptide of human SOCS1 |
Storage Buffer | Store at -20℃. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
Synonym | JAB; CIS1; SSI1; TIP3; CISH1; SSI-1; SOCS-1; |
Western blot analysis of extracts of various cell lines, using SOCS1 antibody.
Immunohistochemistry of paraffin-embedded mouse brain using SOCS1 antibody at dilution of 1:100 (x40 lens).
Immunohistochemistry of paraffin-embedded human stomach using SOCS1 antibody at dilution of 1:100 (x40 lens).
Immunohistochemistry of paraffin-embedded human esophagus using SOCS1 antibody at dilution of 1:100 (x40 lens).
Immunohistochemistry of paraffin-embedded rat liver using SOCS1 antibody at dilution of 1:100 (x40 lens).
Immunohistochemistry of paraffin-embedded mouse brain using SOCS1 antibody.
Immunohistochemistry of paraffin-embedded rat liver using SOCS1 antibody.
Immunohistochemistry of paraffin-embedded human stomach using SOCS1 antibody.
This gene encodes a member of the STAT-induced STAT inhibitor (SSI), also known as suppressor of cytokine signaling (SOCS), family. SSI family members are cytokine-inducible negative regulators of cytokine signaling. The expression of this gene can be induced by a subset of cytokines, including IL2, IL3 erythropoietin (EPO), CSF2/GM-CSF, and interferon (IFN)-gamma. The protein encoded by this gene functions downstream of cytokine receptors, and takes part in a negative feedback loop to attenuate cytokine signaling. Knockout studies in mice suggested the role of this gene as a modulator of IFN-gamma action, which is required for normal postnatal growth and survival.
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