SPHK1-Polyclonal Antibodies

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SPHK1

Qty


Total
$220
Catalog #
A0139
Antibody Type
Polyclonal Antibody
Gene ID
8877
Swiss Prot
Q9NYA1
Size
Species
Rabbit
Isotype
IgG
Purity
Affinity purification
Additional Information
ReactivityHuman Mouse Rat
Tested applicationsWB IHC IF
Recommended DilutionWB 1:500 - 1:2000 IHC 1:50 - 1:200 IF 1:50 - 1:200
Calculated MW43kDa
Observed MWRefer to Figures
ImmunogenRecombinant protein of human SPHK1
Storage BufferStore at -20℃. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Concentrationab
SynonymPHK1; SPHK
Images
  • A0139: image 1

    Western blot analysis of extracts of various cell lines, using SPHK1 antibody.

  • A0139: image 2

    Immunohistochemistry of paraffin-embedded human stomach cancer using SPHK1 antibody at dilution of 1:200 (x400 lens).

  • A0139: image 3

    Immunohistochemistry of paraffin-embedded Rat liver using SPHK1 antibody at dilution of 1:100 (x400 lens).

  • A0139: image 4

    Immunofluorescence analysis of HeLa cell using SPHK1 antibody.

Background

Sphingosine kinases (SPHKs) catalyze the phosphorylation of sphingosine to form sphingosine-1-phosphate (S1P), a lipid mediator with both intra- and extracellular functions. Together with other sphingolipid metobolizing enzymes, SPHKs regulate the balance of the lipid mediators, ceramide, sphingosine, and S1P (1-4). Two distinct SPHK isoforms, SPHK1 and SPHK2, have been cloned and characterized (5,6). SPHK1 and SPHK2 are highly conserved and diverselly expressed (7,8). The SPHKs are activated by G-protein-coupled receptors, receptor tyrosine kinases, immunoglobulin receptors, cytokines, and other stimuli (9-12). The molecular mechanisms by which SPHK1 and SPHK2 are specifically regulated are complex and only partially understood.

Protocol

N/A

MSDS
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