SPTAN1-Polyclonal Antibodies

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SPTAN1

Qty


Total
$380
Catalog #
A0160
Antibody Type
Polyclonal Antibody
Gene ID
6709
Swiss Prot
Q13813
Size
Species
Rabbit
Isotype
IgG
Purity
Affinity purification
Additional Information
ReactivityHuman Mouse Rat
Tested applicationsWB IHC IP
Recommended DilutionWB 1:500 - 1:2000 IHC 1:50 - 1:200 IP 1:20 - 1:50
Calculated MW285/150kDa
Observed MWRefer to Figures
ImmunogenA synthetic peptide of human SPTAN1
Storage BufferStore at -20℃. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Synonym(ALPHA)II; SPTAN1;EIEE5;NEAS;SPTA2;
Images
  • A0160: image 1

    Western blot analysis of extracts of various cell lines, using SPTAN1 antibody.

Background

Alpha Fodrin is a member of the spectrin family of widely distributed filamentous proteins that form a supporting and organizing scaffold for cell membranes. Non-erythroid alpha spectrin, also called Alpha Fodrin, is a major cortical cytoskeletal protein that has been implicated in the establishment of specialized membrane- cytoskeletal domains in differentiating cells. Cleavage of Alpha Fodrin accompanies apoptosis, induced by activation via the CD3/T cell receptor complex, ligation of the Fas (CD95) molecule and other Fas-expressing cells, or treatment of cells with staurosporine, dexamethasone, or synthetic ceramide. The major products of the cleavage are amino-terminal (150 kDa) and carboxy-terminal (120 kDa and 35 kDa) fragments. Antibodies against Alpha Fodrin are observed in diseases characterized by chronic apoptosis, and are valuable in the evaluation fo Sicca- and Sj

Protocol

N/A

MSDS
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