SRSF1-Monoclonal Antibodies

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SRSF1

Qty


Total
$220
Catalog #
A1649
Antibody Type
Polyclonal Antibody
Gene ID
6426
Swiss Prot
Q07955
Size
Species
Rabbit
Isotype
IgG
Purity
Affinity purification
Additional Information
ReactivityHuman Mouse Rat
Tested applicationsWB IHC IF
Recommended DilutionWB 1:500 - 1:2000 IHC 1:50 - 1:200 IF 1:50 - 1:200
Calculated MW28kDa
Observed MWRefer to Figures
ImmunogenRecombinant Protein of human SRSF1
Storage BufferStore at -20℃. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
SynonymASF; MGC5228; SF2; SF2p33; SRp30a;
Images
  • A1649: image 1

    Western blot analysis of extracts of various cells, using SRSF1 antibody.

  • A1649: image 2

    Immunohistochemistry of paraffin-embedded rat lung using SRSF1 antibody at dilution of 1:100 (x400 lens).

  • A1649: image 3

    Immunohistochemistry of paraffin-embedded human lung cancer using SRSF1 antibody at dilution of 1:100 (x400 lens).

  • A1649: image 4

    Immunohistochemistry of paraffin-embedded mouse esophagus using SRSF1 antibody at dilution of 1:100 (x400 lens).

  • A1649: image 5

    Immunofluorescence analysis of U2OS cell using SFRS1 antibody. Blue: DAPI for nuclear staining.

Background

SF2/ASF is a member of the Ser-Arg-rich (SR) protein family of highly conserved nuclear phosphoproteins involved in pre-mRNA splicing (1). Besides its role in nuclear pre-mRNA splicing, SF2/ASF has been shown to shuttle between the nucleus and cytoplasm, suggesting additional roles in mRNA transport and cytoplasmic events (2). SF2/ASF associates with translating ribosomes and stimulates translation (3). It also activates translation initiation by suppressing the activity of 4E-BP1, which is mediated by SF2/ASF association with mTOR and the phosphatase PP2A (4). More recent studies have demonstrated a role for SF2/ASF in microRNA processing (5).

Protocol

N/A

MSDS
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