STAT1-Polyclonal Antibodies

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STAT1

Qty


Total
$220
Catalog #
A0027
Antibody Type
Polyclonal Antibody
Gene ID
6772
Swiss Prot
P42224
Size
Species
Rabbit
Isotype
IgG
Purity
Affinity purification
Additional Information
ReactivityHuman Mouse Rat
Tested applicationsWB IHC IF
Recommended DilutionWB 1:500 - 1:2000 IHC 1:50 - 1:200 IF 1:50 - 1:200
Calculated MW83kDa
Observed MWRefer to Figures
ImmunogenRecombinant protein of human STAT1
Storage BufferStore at -20℃. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Concentrationbkoq
SynonymSTAT1;DKFZp686B04100;ISGF-3;STAT91 ;
Images
  • A0027: image 1

    Western blot analysis of various cell lines, using STAT1 antibody.

  • A0027: image 2

    Immunofluorescence analysis of HeLa cell using STAT1 antibody. Blue: DAPI for nuclear staining.

Background

The Stat1 transcription factor is activated in response to a large number of ligands (1) and is essential for responsiveness to IFN-α and IFN-γ (2,3). Phosphorylation of Stat1 at Tyr701 induces Stat1 dimerization, nuclear translocation, and DNA binding (4). Stat1 protein exists as a pair of isoforms, Stat1α (91 kDa) and the splice variant Stat1β (84 kDa). In most cells, both isoforms are activated by IFN-α, but only Stat1α is activated by IFN-γ. The inappropriate activation of Stat1 occurs in many tumors (5). In addition to tyrosine phosphorylation, Stat1 is also phosphorylated at Ser727 through a p38 mitogen-activated protein kinase (MAPK)-dependent pathway in response to IFN-α and other cellular stresses (6). Serine phosphorylation may be required for the maximal induction of Stat1-mediated gene activation.

Protocol

N/A

MSDS
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