SUMO2-Monoclonal Antibodies

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SUMO2

Qty


Total
$220
Catalog #
A2486
Antibody Type
Polyclonal Antibody
Gene ID
6613
Swiss Prot
P61956
Size
Species
Rabbit
Isotype
IgG
Purity
Affinity purification
Additional Information
ReactivityHuman Mouse Rat
Tested applicationsWB IHC
Recommended DilutionWB 1:500 - 1:1000 IHC 1:50 - 1:100
Calculated MW18kDa
Observed MWRefer to Figures
ImmunogenRecombinant protein of human SUMO2
Storage BufferStore at -20℃. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Concentrationhop
SynonymSUMO2;HSMT3;MGC117191;SMT3B;SMT3H2;SUMO3;Smt3A;HSMT3;SMT3 homolog 2;SUMO-3;Sentrin-2 ; Ubiquitin-like protein SMT3A ;
Images
  • A2486: image 1

    Western blot analysis of extracts of various cell lines, using SUMO2 antibody.

  • A2486: image 2

    Immunohistochemistry of paraffin-embedded rat lung using SUMO2 antibody at dilution of 1:200 (400x lens).

  • A2486: image 3

    Immunohistochemistry of paraffin-embedded rat kidney using SUMO2 antibody at dilution of 1:200 (400x lens).

  • A2486: image 4

    Immunohistochemistry of paraffin-embedded human lung cancer using SUMO2 antibody at dilution of 1:200 (400x lens).

  • A2486: image 5

    Immunohistochemistry of paraffin-embedded human kidney cancer using SUMO2 antibody at dilution of 1:200 (400x lens).

  • A2486: image 6

    Immunohistochemistry of paraffin-embedded human stomach cancer using SUMO2 antibody at dilution of 1:200 (400x lens).

Background

Small ubiquitin-related modifier 1, 2 and 3 (SUMO-1, -2 and -3) are members of the ubiquitin-like protein family (1). The covalent attachment of the SUMO-1, -2 or -3 (SUMOylation) to target proteins is analogous to ubiquitination. This post-translational modification is a reversible, multi-step process that is initiated by cleaving a precursor protein to a mature protein. Mature SUMO-1, -2 or -3 is then linked to the activating enzyme E1, conjugated to E2 and in conjunction with E3, SUMO-1, -2 or -3 is ligated to the target protein (2). Ubiquitin and the individual SUMO family members are all targeted to different proteins with diverse biological functions. Ubiquitin predominantly regulates degradation of its target (1). In contrast, SUMO-1 is conjugated to RanGAP, PML, p53 and IκB-α to regulate nuclear trafficking, formation of subnuclear structures, regulation of transcriptional activity and protein stability (3-7). SUMO-2/-3 forms poly-(SUMO) chains, is conjugated to topoisomerase II and APP, regulates chromosomal segregation and cellular responses to environmental stress, and plays a role in the progression of Alzheimer disease (8-11).

Protocol

N/A

MSDS
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