SYT1-Monoclonal Antibodies

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SYT1

Qty


Total
$220
Catalog #
A0992
Antibody Type
Polyclonal Antibody
Gene ID
6857
Swiss Prot
P21579
Size
Species
Rabbit
Isotype
IgG
Purity
Affinity purification
Additional Information
ReactivityHuman Mouse Rat
Tested applicationsWB IHC IF
Recommended DilutionWB 1:500 - 1:2000 IHC 1:50 - 1:200 IF 1:50 - 1:200
Calculated MW48kDa
Observed MWRefer to Figures
ImmunogenRecombinant protein of human SYT1
Storage BufferStore at -20℃. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
SynonymSYT1;DKFZp781D2042;P65;SVP65;SYT ;
Images
  • A0992: image 1

    Western blot analysis of extracts of various cell lines, using SYT1 antibody.

  • A0992: image 2

    Immunohistochemistry of paraffin-embedded rat kidney using SYT1 antibody at dilution of 1:200 (400x lens).

  • A0992: image 3

    Immunofluorescence analysis of HeLa cell using SYT1 antibody. Blue: DAPI for nuclear staining.

Background

Synaptotagmin 1 (SYT1) is an integral membrane protein found in synaptic vesicles thought to play a role in vesicle trafficking and exocytosis (1). Individual SYT1 proteins are composed of an amino-terminal transmembrane region, a central linker region and a pair of carboxy-terminal C2 domains responsible for binding Ca2+ (2). The C2 domains appear to be functionally distinct, with the C2A domain responsible for regulating synaptic vesicle fusion in a calcium-dependent manner during exocytosis while the C2B domain allows for interaction between adjacent SYT1 proteins (3). Because synaptotagmin 1 binds calcium and is found in synaptic vesicles, this integral membrane protein is thought act as a calcium sensor in fast synaptic vesicle exocytosis. Evidence suggests possible roles in vesicle-mediated endocytosis and glucose-induced insulin secretion as well (4,5). SYT1 binds several different SNARE proteins during calcium-mediated vesicle endocytosis and an association between SYT1 and the SNARE protein SNAP-25 is thought to be a key element in vesicle-mediated exocytosis (6).

Protocol

N/A

MSDS
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