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Reactivity | Human Mouse Rat |
Tested applications | WB IHC |
Recommended Dilution | WB 1:500 - 1:2000 IHC 1:50 - 1:100 |
Calculated MW | 12kDa |
Observed MW | Refer to figures |
Immunogen | Recombinant protein of human TCEB1 |
Storage Buffer | Store at -20℃. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
Synonym | SIII; eloC; |
Western blot analysis of extracts of various cell lines, using TCEB1 antibody.
Immunohistochemistry of paraffin-embedded mouse liver using TCEB1 antibody.
Immunohistochemistry of paraffin-embedded rat kidney using TCEB1 antibody.
Immunohistochemistry of paraffin-embedded human prostate using TCEB1 antibody.
Immunohistochemistry of paraffin-embedded human stomach using TCEB1 antibody.
This gene encodes the protein elongin C, which is a subunit of the transcription factor B (SIII) complex. The SIII complex is composed of elongins A/A2, B and C. It activates elongation by RNA polymerase II by suppressing transient pausing of the polymerase at many sites within transcription units. Elongin A functions as the transcriptionally active component of the SIII complex, whereas elongins B and C are regulatory subunits. Elongin A2 is specifically expressed in the testis, and capable of forming a stable complex with elongins B and C. The von Hippel-Lindau tumor suppressor protein binds to elongins B and C, and thereby inhibits transcription elongation. Multiple alternatively spliced transcript variants encoding two distinct isoforms have been identified.
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