TCF4-Methylated Antibodies

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TCF4

Qty


Total
$220
Catalog #
A1141
Antibody Type
Polyclonal Antibody
Gene ID
6925
Swiss Prot
P15884
Size
Species
Rabbit
Isotype
IgG
Purity
Affinity purification
Additional Information
ReactivityHuman Mouse Rat
Tested applicationsWB IHC IF
Recommended DilutionWB 1:500 - 1:2000 IHC 1:50 - 1:200 IF 1:50 - 1:200
Calculated MW71kDa
Observed MWRefer to Figures
ImmunogenRecombinant protein of human TCF4
Storage BufferStore at -20℃. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Concentrationk
SynonymE2-2;ITF2;PTHS;SEF2;ITF-2;SEF-2;TCF-4;SEF2-1;SEF2-1A;SEF2-1B; bHLHb19
Images
  • A1141: image 1

    Western blot analysis of extracts of various cell lines, using TCF4 antibody.

  • A1141: image 2

    Immunofluorescence analysis of HeLa cell using TCF4 antibody. Blue: DAPI for nuclear staining.

Background

LEF1 and TCF are members of the high mobility group (HMG) DNA binding protein family of transcription factors that consists of the following: Lymphoid Enhancer Factor 1 (LEF1), T Cell Factor 1 (TCF1), TCF3, and TCF4 (1). LEF1 and TCF1 were originally identified as important factors regulating early lymphoid development (2) and act downstream in Wnt signaling. LEF1 and TCF bind to Wnt response elements to provide docking sites for β-catenin, which translocates to the nucleus to promote the transcription of target genes upon activation of Wnt signaling (3). LEF1 and TCF are dynamically expressed during development and aberrant activation of the Wnt signaling pathway is involved in many types of cancers including colon cancer (4,5).

Protocol

N/A

MSDS
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