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sales@neoscientific.com
+1-888.733.6849
+1-617.299.7367 (Int’l)
+1-888.733.6849
+1-617.299.7367 (Int’l)
| Reactivity | Human Mouse Rat |
| Tested applications | WB IHC |
| Recommended Dilution | WB 1:500 - 1:2000 IHC 1:50 - 1:200 |
| Calculated MW | 23kDa |
| Observed MW | Refer to Figures |
| Immunogen | Recombinant protein of human TIRAP |
| Storage Buffer | Store at -20℃. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Concentration | s |
| Synonym | Mal; wyatt; BACTS1; MyD88-2; |
Western blot analysis of extracts of various cells, using TIRAP antibody.
Immunohistochemistry of paraffin-embedded human liver cancer using TIRAP antibody at dilution of 1:200 (40x lens).
Immunohistochemistry of paraffin-embedded human colon carcinoma using TIRAP antibody at dilution of 1:200 (40x lens).
Immunohistochemistry of paraffin-embedded mouse kidney using TIRAP antibody at dilution of 1:100 (x40 lens).
Immunohistochemistry of paraffin-embedded rat kidney using TIRAP antibody at dilution of 1:100 (x40 lens).
Immunohistochemistry of paraffin-embedded mouse liver using TIRAP antibody at dilution of 1:100 (x40 lens).
The innate immune system recognizes microbial pathogens through Toll-like receptors (TLRs), which identify pathogen-associated molecular patterns. Different TLRs recognize different pathogen-associated molecular patterns and all TLRs have a Toll-interleukin 1 receptor (TIR) domain, which is responsible for signal transduction. The protein encoded by this gene is a TIR adaptor protein involved in the TLR4 signaling pathway of the immune system. It activates NF-kappa-B, MAPK1, MAPK3 and JNK, which then results in cytokine secretion and the inflammatory response. Alternative splicing of this gene results in several transcript variants; however, not all variants have been fully described.
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