TLR8-Methylated Antibodies

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TLR8

Qty


Total
$220
Catalog #
A1489
Antibody Type
Polyclonal Antibody
Gene ID
51311
Swiss Prot
Q9NR97
Size
Species
Rabbit
Isotype
IgG
Purity
Affinity purification
Additional Information
ReactivityHuman Mouse Rat
Tested applicationsWB IHC IF
Recommended DilutionWB 1:500 - 1:2000 IHC 1:50 - 1:200 IF 1:50 - 1:200
Calculated MW120kDa
Observed MWRefer to Figures
ImmunogenRecombinant protein of human TLR8
Storage BufferStore at -20℃. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Concentrations
SynonymCD288; TLR8
Images
  • A1489: image 1

    Western blot analysis of extracts of various cell lines,using TLR8 antibody.

  • A1489: image 2

    Immunofluorescence analysis of MCF7 cell using TLR8 antibody. Blue: DAPI for nuclear staining.

Background

The Toll-like Receptors (TLR) are a family of human receptors that share homology with the Drosophila Toll Receptors, which are involved in mediating dorsoventral polarization in developing Drosophila embryos and participate in host immunity. The TLR family members are characterized by a highly conserved Toll homology (TH) domain, which is essential for Toll-induced signal transductions. TLRs are type I transmembrane receptors that contain an extracellular domain consisting of several leucine-rich regions and a single cytoplasmic Toll/IL-1R like domain. Three TLR family members, TLR7, TLR8 and TLR9, belong to a subfamily of TLRs which are differentially expressed. TLR7 is expressed in lung, placenta and spleen. TLR8 is expressed in lung and peripheral blood leukocytes, and TLR9 is predominantly expressed in spleen, lymph nodes, bone marrow and peripheral blood leukocytes. TLR7, TLR8 and TLR9 stimulate the NF˚B signaling pathway, suggesting that they play a role in the immune response.

Protocol

N/A

MSDS
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