TPH1-Monoclonal Antibodies

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TPH1

Qty


Total
$220
Catalog #
A1569
Antibody Type
Polyclonal Antibody
Gene ID
7166
Swiss Prot
P17752
Size
Species
Rabbit
Isotype
IgG
Purity
Affinity purification
Additional Information
ReactivityHuman Mouse Rat
Tested applicationsWB IHC
Recommended DilutionWB 1:500 - 1:2000 IHC 1:50 - 1:200
Calculated MW55kDa
Observed MWRefer to Figures
ImmunogenRecombinant protein of human TPH1
Storage BufferStore at -20℃. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
SynonymTPH1;MGC119994;TPRH;TRPH;Tryptophan 5-hydroxylase 1;
Images
  • A1569: image 1

    Western blot analysis of extracts of THP-1 cell lines, using TPH1 antibody.

Background

Tryptophan hydroxylase (TPH) is the rate-limiting enzyme in the biosynthesis of serotonin (1) by converting tryptophan to 5-hydroxy-L-tryptophan (2). Two isoforms of TPH exist: TPH-1 is mainly expressed in the periphery, whereas the expression of TPH-2 is restricted to neuronal cells and the central nervous system (3). Most of the serotonin found throughout the body is synthesized by TPH-1 in enterochromaffin cells of the gastrointestinal tract. Targeted disruption of the tph1 gene results in low levels of circulating and tissue serotonin (4).

Protocol

N/A

MSDS
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