UBE2I-Polyclonal Antibodies

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UBE2I

Qty


Total
$220
Catalog #
A0105
Antibody Type
Polyclonal Antibody
Gene ID
7329
Swiss Prot
P63279
Size
Species
Rabbit
Isotype
IgG
Purity
Affinity purification
Additional Information
ReactivityHuman
Tested applicationsWB IHC
Recommended DilutionWB 1:500 - 1:1000 IHC 1:50 - 1:100
Calculated MW18kDa
Observed MWRefer to Figures
ImmunogenA synthetic peptide of human UBE2I
Storage BufferStore at 4℃. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Concentrationbfjl
SynonymUBE2I;C358B7.1;P18;UBC9 ;E2,UBE2I
Background

The process of SUMO-1 conjugation is similar to that seen with ubiquitin and other forms of post-translational protein modification (1). Like ubiquitin, SUMO-1 is conjugated to its target protein by the coordinated action of ubiquitin conjugation enzymes E1, E2 and E3 (2). UBE2I (or ube2M) is a highly conserved, 158 amino acid protein that acts as a SUMO-1 conjugating enzyme (3). UBE2I binds to target proteins through their SUMO-1-CS (consensus sequence) domains and interacts with SUMO via the structurally conserved amino-terminal domain (3,4). Localization of UBE2I to the nucleus and the nuclear envelope allows this enzyme to catalyze target protein sumoylation and regulate target protein nucleocytoplasmic transport and transcriptional activity (5,6). UBE2I target proteins include a host of proteins (RAD51, RAD52, p53 and c-Jun) that regulate the cell cycle, DNA repair, and p53-dependent processes (7).

Protocol

N/A

MSDS
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