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sales@neoscientific.com
+1-888.733.6849
+1-617.299.7367 (Int’l)
+1-888.733.6849
+1-617.299.7367 (Int’l)
| Reactivity | Human Mouse Rat |
| Tested applications | WB IHC |
| Recommended Dilution | WB 1:500 - 1:2000 IHC 1:50 - 1:200 |
| Calculated MW | 148kDa |
| Observed MW | Refer to figures |
| Immunogen | Recombinant protein of human UPF2 |
| Storage Buffer | Store at -20℃. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Synonym | HUPF2; RENT2; smg-3; |
Western blot analysis of extracts of various cell lines, using UPF2 antibody.
Immunohistochemistry of paraffin-embedded rat kidney using UPF2 antibody at dilution of 1:200 (40x lens).
Immunohistochemistry of paraffin-embedded human lung using UPF2 antibody at dilution of 1:100 (40x lens).
Immunohistochemistry of paraffin-embedded human prostate using UPF2 antibody at dilution of 1:100 (40x lens).
This gene encodes a protein that is part of a post-splicing multiprotein complex involved in both mRNA nuclear export and mRNA surveillance. mRNA surveillance detects exported mRNAs with truncated open reading frames and initiates nonsense-mediated mRNA decay (NMD). When translation ends upstream from the last exon-exon junction, this triggers NMD to degrade mRNAs containing premature stop codons. This protein is located in the perinuclear area. It interacts with translation release factors and the proteins that are functional homologs of yeast Upf1p and Upf3p. Two splice variants have been found for this gene; both variants encode the same protein.
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