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+1-888.733.6849
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| Reactivity | Human |
| Tested applications | WB IHC IF |
| Recommended Dilution | WB 1:500 - 1:2000 IHC 1:100 - 1:200 IF 1:20 - 1:100 |
| Calculated MW | 82kDa |
| Observed MW | Refer to Figures |
| Immunogen | Recombinant protein of human XRCC5 |
| Storage Buffer | Store at -20℃. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Concentration | ej |
| Synonym | KU80; KUB2; Ku86; NFIV; KARP1; KARP-1 |
Western blot analysis of extracts of various cell lines, using XRCC5 antibody.
Immunohistochemistry of paraffin-embedded Human adenomyosis using XRCC5 antibody at dilution of 1:100 (40x lens).
Immunohistochemistry of paraffin-embedded Human gastric using XRCC5 antibody at dilution of 1:100 (40x lens).
Immunohistochemistry of paraffin-embedded Human gastric cancer using XRCC5 antibody at dilution of 1:100 (40x lens).
Immunohistochemistry of paraffin-embedded Human mammary cancer using XRCC5 antibody at dilution of 1:100 (40x lens).
Immunohistochemistry of paraffin-embedded human prostate cancer using XRCC5 antibody at dilution of 1:100 (40x lens).
Immunohistochemistry of paraffin-embedded human esophagus using XRCC5 antibody at dilution of 1:100 (40x lens).
Immunohistochemistry of paraffin-embedded human stomach using XRCC5 antibody at dilution of 1:100 (40x lens).
Immunofluorescence analysis of A549 cell using XRCC5 antibody. Blue: DAPI for nuclear staining.
Immunofluorescence analysis of U2OS cell using XRCC5 antibody.
Immunofluorescence analysis of HeLa cell using XRCC5 antibody.
Immunofluorescence analysis of HeLa cell using XRCC5 antibody.
The protein encoded by this gene is the 80-kilodalton subunit of the Ku heterodimer protein which is also known as ATP-dependant DNA helicase II or DNA repair protein XRCC5. Ku is the DNA-binding component of the DNA-dependent protein kinase, and it functions together with the DNA ligase IV-XRCC4 complex in the repair of DNA double-strand break by non-homologous end joining and the completion of V(D)J recombination events. This gene functionally complements Chinese hamster xrs-6, a mutant defective in DNA double-strand break repair and in ability to undergo V(D)J recombination. A rare microsatellite polymorphism in this gene is associated with cancer in patients of varying radiosensitivity.
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