ARFIP2 Human-ADP-Ribosylation Factor

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ARFIP2 Human

Qty


Total
$65
Catalog #
PRPS-1208
Size
Description
ARFIP2 Human Recombinant produced in E. coli is a single polypeptide chain containing 364 amino acids (1-341) and having a molecular mass of 40.2 kDa.ARFIP2 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
Additional Information
IntroductionArfaptin 2 (ARFIP2) is a Rac1 binding protein essential for Rac-mediated actin polymerization and the succeeding formation of membrane ruffles and lamellipodia. ARFIP2 is a putative target protein of ADP-ribosylation factor. ARFIP2 is also involved in membrane ruffling. ARFIP2 expression is increased at sites of neurodegeneration. In addition, ARFIP2 interacts with the ADP ribosylation factor ARF6, a GTPase which associates with the plasma membrane and intracellular endosome vesicles, in a GTP dependent mode. Furthermore, Arfaptin 2 controls the aggregation of mutant Huntingtin protein by weakening proteasome function.
SynonymsADP-ribosylation factor interacting protein 2, partner of RAC1 (arfaptin 2), Partner of RAC1, Protein POR1, arfaptin-2, POR1.
SourceE.coli.
Physical AppearanceSterile Filtered colorless solution.
FormulationThe ARFIP2 solution (0.25mg/1ml) contains 20mM Tris-HCl buffer (pH 8.0), 0.2M NaCl, 1mM DTT and 40% glycerol.
StabilityStore at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Amino Acid SequenceMGSSHHHHHH
SSGLVPRGSH
MGS
TDGILG
KAATMEIPIH
GNGEARQLPE
DDGLEQDLQQ
VMVSGPNLNE
TSIVSGGYGG
SGDGLIPTGS
GRHPSHSTTP
SGPGDEVARG
IAGEKFDIVK
KWGINTYKCT
KQLLSERFGR
GSRTVDLELE
LQIELLRETK
RKYESVLQLG
RALTAHLYSL
LQTQHALGDA
FADLSQKSPE
LQEEFGYNAE
TQKLLCKNGE
TLLGAVNFFV
SS
PurityGreater than 90% as determined by SDS-PAGE.
UsageNeoScientific's products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drµgs, agricultural or pesticidal products, food additives or household chemicals.
Background

N/A

Protocol

N/A

MSDS
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