Atosiban also called ADH (Anti-Diuretic Hormone) has a molecular formula of C43H67N11O12S2 , C[Mpr-D-Tyr(OEt)-Ile-Thr-Asn-Cys]-Pro-Orn-Gly-NH2 having a Mw of 994.2 Dalton is the first oxytocin antagonist to be specifically developed for the treatment of preterm labour. Atosiban has a specific mode of action, inhibiting oxytocin-induced uterine contractions by blocking oxytocin receptors in the uterus. Extensive clinical investigations have shown Atosiban to be at least as effective as current tocolytic agents. In addition, due to its novel and specific mode of action, Atosiban has a markedly improved maternal side effects profile compared with conventional therapies.
Sterile Filtered White lyophilized (freeze-dried) powder.
The Atosiban peptide was lyophilized with no additives.
It is recommended to reconstitute the lyophilized Atosiban in sterile 18MΩ-cm H2O not less than 100µg/ml, which can then be further diluted to other aqueous solutions.
Lyophilized Atosiban althoµgh stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution Atosiban should be stored at 4°C between 2-7 days and for future use below -18°C. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Please prevent freeze-thaw cycles.
Greater than 99.0% as determined by(a) Analysis by RP-HPLC.(b) Analysis by SDS-PAGE.
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