BCL10 Human-B Cell Lymphoma

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BCL10 Human

Qty


Total
$65
Catalog #
PRPS-1065
Size
Description
BCL10 Human Recombinant produced in E. coli is a single polypeptide chain containing 257 amino acids (1-233) and having a molecular mass of 28.8kDa (molecular weight on SDS-PAGE will appear higher).BCL10 is fused to a 24 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
Additional Information
IntroductionBCL10 holds a caspase recruitment domain (CARD), and is known as an inducer of apoptosis and as NF-kappaB activator. BCL10 cooperates with other CARD domain containing proteins such as CARD9, 10, 11 and 14, which operates as upstream regulators in NF-kappaB signaling. BCL10 is known to create a complex with MALT1, a protein encoded by another gene and is translocated in MALT lymphoma. MALT1 and BCL10 protein synergize the activation of NF-kappaB, and the deregulation of either of them facilitates the same pathogenetic process which leads to the malignancy.
SynonymsB-cell CLL/lymphoma 10, B-cell lymphoma/leukemia 10, Mammalian CARD-containing adapter molecule E10, CARD-containing molecule enhancing NF-kappa-B, CED-3/ICH-1 prodomain homologous E10-like regulator, CARD-containing apoptotic signaling protein, caspase-r
SourceE.coli.
Physical AppearanceSterile Filtered colorless solution.
FormulationThe BCL10 solution (1mg/ml) contains 20mM Tris-HCl buffer (pH 8.0), 50mM Nacl, 1mM DTT and 10% glycerol.
StabilityStore at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Amino Acid SequenceMGSSHHHHHH
SSGLVPRGSH
MGSHMEPTAP
SLTEEDLTEV
KKDALENLRV
YLCEKIIAER
HFDHLRAKKI
LSREDTEEIS
CRTSSRKRAG
KLLDYLQENP
KGLDTLVESI
RREKTQNFLI
QKITDEVLKL
RNIKLEHLKG
LKCSSCEPFP
DGATNNLSRS
NSDESNFSEK
LRASTVMYHP
EGESSTTPFF
STNSSLNLPV
LEVGRTENTI
FSSTTLPRPG
DPGAPPLPPD
LQ
PurityGreater than 85% as determined by SDS-PAGE.
UsageNeoScientific's products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drµgs, agricultural or pesticidal products, food additives or household chemicals.
Background

N/A

Protocol

N/A

MSDS
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