BCL2 Human, His-B Cell Lymphoma

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BCL2 Human, His

Qty


Total
$65
Catalog #
PRPS-690
Size
Description
BCL2 Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing amino acids 1-211 and having a molecular mass of 25.4 kDa. The BCL2 is fused to a 20 a.a. His-Tag at N-terminus and purified by proprietary chromatographic techniques.
Additional Information
IntroductionBCL2 gene encodes an integral outer mitochondrial membrane protein that blocks the apoptotic death of some cells such as lymphocytes. Constitutive expression of BCL2, such as in the case of translocation of BCL2 to Ig heavy chain locus, is thoµght to be the cause of follicular lymphoma. Two transcript variants, produced by alternate splicing, differ in their C-terminal ends.
SynonymsApoptosis regulator Bcl-2, BCL2, B-cell CLL/lymphoma 2, Bcl-2.
SourceEscherichia Coli.
Physical AppearanceSterile filtered colorless solution.
FormulationThe BCL2 protein solution contains 20mM Tris-HCl, pH-8, 2mM DTT and 20% glycerol.
StabilityStore at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Amino Acid SequenceMGSSHHHHHH
SSGLVPRGSH
MAHAGRTGYD
NREIVMKYIH
YKLSQRGYEW
DAGDVGAAPP
GAAPAPGIFS
SQPGHTPHPA
ASRDPVARTS
PLQTPAAPGA
AAGPALSPVP
PVVHLTLRQA
GDDFSRRYRR
DFAEMSSQLH
LTPFTARGRF
ATVVEELFRD
GVNWGRIVAF
FEFGGVMCVE
SVNREMSPLV
DNIALWMTEY
LNRHLHTWIQ
DNGGWDAFVE
LYGPSMRPLF
D.
PurityGreater than 90.0% as determined by SDS-PAGE.
UsageNeoScientific's products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drµgs, agricultural or pesticidal products, food additives or household chemicals.
Background

N/A

Protocol

N/A

MSDS
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