BIN1 Human-Other

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BIN1 Human

Qty


Total
$65
Catalog #
PRPS-553
Size
Description
BIN1 Recombinant Human produced in E.Coli is a single, non-glycosylated polypeptide chain containing 459 amino acids (1-439 a.a) and having a molecular mass of 50.4 kDa. The BIN1 is fused to a 20 amino acid His-Tag at N-terminus and purified by proprietary chromatographic techniques.
Additional Information
IntroductionBIN1 is a nucleocytoplasmic adaptor protein, one of which was primarily identified as MYC-interacting protein having the characteristics of a tumor suppressor. BIN1 protein interacts with and inhibits the oncogenic activity of the myc oncoprotein that is a key player in many human cancers. The absence of Bin1 contributes to growth deregulation in cancer cells in carcinoma of the breast, colon, lung, cervix, prostate and liver.
SynonymsAMPH2, AMPHL, MGC10367, SH3P9, Amphiphysin II.
SourceEscherichia Coli.
Physical AppearanceSterile filtered colorless solution.
FormulationBIN1 protein solution (1mg/ml) containing 20mM Tris buffer pH-8, 1mM DTT & 10% glycerol.
StabilityStore at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Amino Acid SequenceMGSSHHHHHH
SSGLVPRGSH
MAEMGSKGVT
AGKIASNVQK
KLTRAQEKVL
QKLGKADETK
DEQFEQCVQN
FNKQLTEGTR
LQKDLRTYLA
SVKAMHEASK
KLNECLQEVY
EPDWPGRDEA
NKIAENNDLL
WMDYHQKLVD
QALLTMDTYL
GQFPDIKSRI
AKRGRKLVDY
DSARHHYESL
QTAKKKDEAK
IAKAEEELIK
AQKVFEEMNV
DLQEELPSLW
NSRVGFYVNT
FQ
PurityGreater than 90.0% as determined by SDS-PAGE.
UsageNeoScientific's products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drµgs, agricultural or pesticidal products, food additives or household chemicals.
Background

N/A

Protocol

N/A

MSDS
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