C12ORF5 Human-Chromosome Open Reading Frame

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C12ORF5 Human

Qty


Total
$65
Catalog #
PRPS-058
Size
Description
C12ORF5 Human Recombinant fused with a 24 amino acid His tag at N-terminus produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 294 amino acids (1-270 a.a.) and having a molecular mass of 32.6kDa. The C12ORF5 is purified by proprietary chromatographic techniques.
Additional Information
IntroductionTP53-induced glycolysis and apoptosis regulator (TIGAR or C12ORF5), is a 270 amino acid protein induced by the p53 tumor suppressor pathway that functions to protect against oxidative stress. C12ORF5 specifically functions to block glycolysis, leading the pathway to the pentose phosphate shunt and decreasing the intracellular concentration of reactive oxygen species. Therefore, it is thoµght that C12ORF5 may act to modulate the apoptotic response to p53, thus allowing cells to survive mild or transient stresses.
SynonymsProbable fructose-2,6-bisphosphatase TIGAR, TP53-induced glycolysis and apoptosis regulator, TIGAR, C12orf5.
SourceEscherichia Coli.
Physical AppearanceSterile Filtered colorless solution.
FormulationThe C12ORF5 solution (0.5 mg/ml) contains 20mM Tris-HCl buffer (pH8.0), 0.2M NaCl, 2mM DTT and 10% glycerol.
StabilityC12ORF5 should be stored desiccated below -18°C. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Please prevent freeze-thaw cycles.
Amino Acid SequenceMGSSHHHHHH
SSGLVPRGSH
MGSHMARFAL
TVVRHGETRF
NKEKIIQGQG
VDEPLSETGF
KQAAAAGIFL
NNVKFTHAFS
SDLMRTKQTM
HGILERSKFC
KDMTVKYDSR
LRERKYGVVE
GKALSELRAM
AKAAREECPV
FTPPGGETLD
QVKMRGIDFF
EFLCQLILKE
ADQKEQFSQG
SPSNCLETSL
AEIFPLGKNH
SSKVNSDSGI
PGLAASVLVV
SHGAYMRSLF
DY
PurityGreater than 90.0% as determined by SDS-PAGE.
UsageNeoScientific's products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drµgs, agricultural or pesticidal products, food additives or household chemicals.
Background

N/A

Protocol

N/A

MSDS
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