CBR3 Human-Reductase

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CBR3 Human

Qty


Total
$65
Catalog #
ENPS-435
Size
Description
Recombinant Human CBR3 fused with a 20 amino acid His tag at N-terminus produced in E.Coli is a single, non-glycosylated polypeptide chain containing 297 amino acids (1-277 a.a) and having a molecular mass of 33kDa. CBR3 is purified by proprietary chromatographic techniques.
Additional Information
IntroductionCBR3 catalyzes the reduction of a large number of biologically and pharmacologically active carbonyl compounds to their corresponding alcohols. CBR3 is one of several monomeric NADPH-dependent oxidoreductases. Furthermore, CBR3 contains 3 exons spanning 11.2 kilobases and is strongly linked to another carbonyl reductase gene, the CBR1. It was sµggested that CBR3 mediates 9-cis-retinoic acid-induced cytostatis and is a potential prognostic marker for oral malignancy.CBR3 is identified in the ovary, pancreas, intestine, colon, kidney, brain, thymus, lung, heart, liver, spleen, leukocyte, prostate and the testis.Polymorphisms in CBR3 may give an explanation to interindividual and interethnic variability of doxorubicin pharmacokinetics and pharmacodynamics.
SynonymsCarbonyl reductase [NADPH] 3, NADPH-dependent carbonyl reductase 3, CBR3, carbonyl reductase 3, hCBR3, SDR21C2.
SourceEscherichia Coli.
Physical AppearanceSterile filtered colorless solution.
FormulationThe CBR3 protein contains 20mM Tris-HCl buffer (pH 8.0) and 10% glycerol.
StabilityStore at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Avoid multiple freeze-thaw cycles.
Amino Acid SequenceMGSSHHHHHH
SSGLVPRGSH
MSSCSRVALV
TGANRGIGLA
IARELCRQFS
GDVVLTARDV
ARGQAAVQQL
QAEGLSPRFH
QLDIDDLQSI
RALRDFLRKE
YGGLNVLVNN
AAVAFKSDDP
MPFDIKAEMT
LKTNFFATRN
MCNELLPIMK
PHGRVVNISS
LQCLRAFENC
SEDLQERFHS
ETLTEGDLVD
LMKKFVEDTK
NEVHEREGWP
NSPYGVSKLG
VTVLSRILAR
RL
PurityGreater than 95.0% as determined by analysis by SDS-PAGE.
UsageNeoScientific's products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drµgs, agricultural or pesticidal products, food additives or household chemicals.
Background

N/A

Protocol

N/A

MSDS
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