CD163 Porcine-CD Antigens

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CD163 Porcine

Qty


Total
$65
Catalog #
PRPS-863
Size
Description
CD163 Porcine Recombinant produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 805 amino acids and having a molecular mass of 87kDa.The CD163 is fused to an 8 amino acid His Tag at C-terminus and purified by proprietary chromatographic techniques.
Additional Information
IntroductionCD163 is an acute phase-regulated receptor which participates in the removal and endocytosis of hemoglobin/haptoglobin complexes by macrophages and thus keeps tissues from free hemoglobin-mediated oxidative damage. Furthermore, CD163 partakes in the uptake and recycling of iron, throµgh endocytosis of hemoglobin/haptoglobin and ensuing breakdown of heme. In addition, CD163 binds hemoglobin/haptoglobin complexes in a calcium-dependent and pH-dependent way. CD163 demonstrates greater affinity for complexes of hemoglobin and multimeric haptoglobin of HP-1F phenotype than for complexes of hemoglobin and dimeric haptoglobin of HP-1S phenotype. Moreover, CD163 stimulates a cascade of intracellular signals which involves tyrosine kinase-dependent calcium recruitment, inositol triphosphate formation and secretion of IL-6 & CSF-1.
SynonymsCD-163, Hemoglobin scavenger receptor, macrophage-associated antigen, M130, sCD163, CD163, MM130.
SourceEscherichia Coli.
Physical AppearanceSterile Filtered White lyophilized (freeze-dried) powder.
FormulationThe protein was lyophilized from a 0.2
SolubilityIt is recommended to reconstitute the lyophilized CD163 in sterile 18MΩ-cm H2O not less than 100µg/ml, which can then be further diluted to other aqueous solutions.
StabilityLyophilized CD163 althoµgh stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution CD163 should be storedat 4°C between 2-7 days and for future use below -18°C.For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Please prevent freeze-thaw cycles.
Amino Acid SequenceMDKLRMVLHE
NSGSADLKLR
VVDGVTECSG
RLEVKFQGEW
GTICDDGWDS
DDAAVACKQL
GCPTAVTAIG
RVNASEGTGH
IWLDSVSCHG
HESALWQCRH
HEWGKHYCNH
NEDAGVTCSD
GSDLELRLKG
GGSHCAGTVE
VEIQKLVGKV
CDRSWGLKEA
DVVCRQLGCG
SALKTSYQVY
SKTKATNTWL
FVSSCNGNET
SLWDCKNWQW
GGLSCDHYDE
AKITCSAHRK
PR
PurityGreater than 95.0% as determined by: (a) Analysis by HPLC. (b) Analysis by SDS-PAGE.
UsageNeoScientific's products are furnished forLABORATORY RESEARCHUSEONLY. The product may not be used as drµgs, agricultural or pesticidal products, food additives or household chemicals.
Background

N/A

Protocol

N/A

MSDS
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