CDC42 Human-Cell Division Cycle

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CDC42 Human

Qty


Total
$65
Catalog #
PRPS-734
Size
Description
CDC42 Human Recombinant fused with a 15 amino acid T7 tag at N-terminus produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 203 amino acids (1-188 a.a.) and having a molecular mass of 22.4kDa.The CDC42 is purified by proprietary chromatographic techniques.
Additional Information
IntroductionCDC42 (Cell division cycle 42 isoform 1) is a small GTPase of the Rho-subfamily that regulates signaling pathways which control various cellular functions including cell morphology, migration, endocytosis and cell cycle progression. CDC42 is a plasma membrane-associated small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. In the active state, CDC42 binds to a variety of effector proteins to regulate cellular responses. CDC42 is involved in epithelial cell polarization processes. CDC42 causes the formation of thin, actin-rich surface projections called filopodia. Also, CDC42 regulates actin polymerization throµgh its direct binding to N-WASP (Neural Wiskott-Aldrich syndrome protein), which subsequently activates Arp2/3 complex. Loss of CDC42 function raises endocytotic uptake of apical proteins, as well as apical polarity factors such as Crumbs. The product of oncogene Dbl was described to specifically catalyze the dissociation of GDP from CDC42 protein.
SynonymsCell division control protein 42 homolog, G25K GTP-binding protein, CDC42, G25K, CDC42Hs.
SourceEscherichia Coli.
Physical AppearanceSterile Filtered colorless solution.
FormulationThe CDC42 solution contains 20mM Tris-HCl buffer (pH8.0), 1mM DTT, 10% glycerol and 2mM EDTA.
StabilityStore at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Amino Acid SequenceMASMTGGQQM
GRGSHMQTIK
CVVVGDGAVG
KTCLLISYTT
NKFPSEYVPT
VFDNYAVTVM
IGGEPYTLGL
FDTAGQEDYD
RLRPLSYPQT
DVFLVCFSVV
SPSSFENVKE
KWVPEITHHC
PKTPFLLVGT
QIDLRDDPST
IEKLAKNKQK
PITPETAEKL
ARDLKAVKYV
ECSALTQKGL
KNVFDEAILA
ALEPPEPKKS
RRC.
PurityGreater than 95.0% as determined by SDS-PAGE.
UsageNeoScientific's products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drµgs, agricultural or pesticidal products, food additives or household chemicals.
Background

N/A

Protocol

N/A

MSDS
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