CHD4 Human-Other

our services
our products
Quotations & Ordering:

For quotations, please use our online quotation form, and you may also contact us by


+1-617.299.7367 (Int’l)


+1-617.299.7367 (Int’l)

Our customer service representatives are available 24 hours, Monday through Friday to assist you.

CHD4 Human


Catalog #
CHD4 is a full-length cDNA coding for the human Mi-2 beta isoform having a molecular mass of 221,298 Dalton (pH 5.8). CHD4 protein is fused to a hexa-histidine purification tag.
Additional Information
IntroductionCHD4 is a member of a family of alleged chromodomain helicase-DNA-binding proteins. Biochemically, CHD4 is a component of the nucleosome transformation and deacetylase (NuRD) complex that takes part in transcription regulation. Autoantibodies targeting the CHD4 are a serologic feature of idiopathic inflammatory myopathies (IIM). In IIM Mi-2 antibodies are characterized by diagnostic sensitivity and specificity of approximately 4-18% and 98-100%, respectively. Moreover, anti-CHD4 antibodies are related to dermatomyositis (frequency up to 31%) and have a great positive predictive value for this type of disease subset. Anti-CHD4 are the only defined myositis-specific autoantibodies clearly focused to a nuclear target. An additional slightly outstanding feature of Mi-2 antibodies relates to their frequency in children, which is similar to that in adults.
SynonymsChromodomain Helicase DNA binding protein 4, Mi-2b, Mi2-BETA, CHD-4, ATP-dependent helicase CHD4, Mi-2 autoantigen 218 kDa protein, EC, EC 3.6.1.
SourceSf9 insect cells.
FormulationCHD4 is supplied in 20mM HEPES buffer pH-8.0 and 500mM NaCl.
StabilityStore at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. Avoid multiple freeze-thaw cycles.
PurityGreater than 95% as determined by SDS-PAGE.
UsageNeoScientific's products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drµgs, agricultural or pesticidal products, food additives or household chemicals.
ApplicationsWestern blot with myositis sera ormonoclonal anti-hexa-His-tag antibody.




Neo Scientific welcomes feedback from its customers.

If you have used an our product and would like to share how it has performed, please click on the "Submit Review" button and provide the requested information.

If you have any additional inquiries please email technical services at

Thank you for your support.



Custom Monoclonal Antibody
MassAb Technologies
Free Trial Custom Polyclonal Antibody
You will receive free purified antibodies for validation
Custom Peptides Synthesis

Start from $40/each

new technologies

Optimized for enhanced
expression levels
XPromoter 2.0
E.coli/insect cells/293 & CHO

3 in 1 expression system
MassAb Technologies

Cover All Epitopes