CHGB Human-Chromogranin

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CHGB Human

Qty


Total
$65
Catalog #
PRPS-831
Size
Description
CHGB Human Recombinant produced in E.Coli is a single, non-glycosylated,polypeptide chain containing 677 amino acids(21-677 a.a.) and having a molecular mass of 78.4kDa. CHGB protein is fused to a 20 amino acid His-Tag at N-terminus and purified by standard chromatography.
Additional Information
IntroductionCHGB is a neuroendocrine secretory granule protein, that is the precursor for other biologically active peptides. CHGB is part of the chromogranin/secretogranin protein family and is expressed in the adrenal medulla, and in pheochromocytoma.
SynonymsSCG1, Secretogranin 1, secretogranin B, CHGB, Sgl, CgB.
SourceEscherichia Coli.
Physical AppearanceSterile filtered colorless solution.
FormulationThe CHGB protein 0.25mg/ml solution containing 20mM Tris-HCl pH-8, 0.15M NaCl & 10% glycerol.
StabilityStore at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Amino Acid SequenceMGSSHHHHHH
SSGLVPRGSH
MPVDNRNHNE
GMVTRCIIEV
LSNALSKSSA
PPITPECRQV
LKTSRKDVKD
KETTENENTK
FEVRLLRDPA
DASEAHESSS
RGEAGAPGEE
DIQGPTKADT
EKWAEGGGHS
RERADEPQWS
LYPSDSQVSE
EVKTRHSEKS
QREDEEEEEG
ENYQKGERGE
DSSEEKHLEE
PGETQNAFLN
ERKQASAIKK
EELVARSETH
AAGHSQEKTH
SR
PurityGreater than 80% as determined by SDS-PAGE.
UsageNeoScientific's products are furnished forLABORATORY RESEARCHUSEONLY. They may not be used as drµgs, agricultural or pesticidal products, food additives or household chemicals.
ReferencesTitle: Secretoneurin promotes neuroprotection and neuronal plasticity via the Jak2/Stat3 pathway in murine models of stroke.Publication:The Journal of Clinical Investigation, http://www.jci.org, Volume 118, Number 1, January 2008.Link:http://www.jci.org/articles/view/32723/files/pdf Applications: CHGB acts directly on neurons after hypoxia and ischemic insult to further their survival by activating the Jak2/Stat3 pathway.
Background

N/A

Protocol

N/A

MSDS
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