CLIC4 Human-Chloride Intracellular Channel

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CLIC4 Human

Qty


Total
$65
Catalog #
PRPS-180
Size
Description
CLIC4 Human Recombinant fused with a 20 amino acid His tag at N-terminus produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 273 amino acids (1-253 a.a.) and having a molecular mass of 30.9kDa. The CLIC4 is purified by proprietary chromatographic techniques.
Additional Information
IntroductionChloride intracellular channel 4 (CLIC4) belongs to the p64 family; CLIC4 is expressed in various tissues and exhibits an intracellular vesicular pattern in Panc-1 cells (pancreatic cancer cells). CLIC4 is a 253 amino acid single-pass membrane protein which localizes to both the nucleus and the cytoplasm and contains one GST C-terminal domain. CLIC4 acts as a monomer which is able to form selective ion channels in target proteins, thus facilitating the transport of chloride and other ions. CLIC4 is believed to have a role in apoptosis and is able to translocate to the nucleus under stress conditions.
SynonymsChloride intracellular channel protein 4, Intracellular chloride ion channel protein p64H1, CLIC4, H1, huH1, p64H1, CLIC4L, MTCLIC, FLJ38640, DKFZp566G223.
SourceEscherichia Coli.
Physical AppearanceSterile Filtered colorless solution.
FormulationThe CLIC4 solution (0.5 mg/ml) contains 20mM Tris-HCl buffer (pH8.0), 0.1M NaCl, 1mM DTT and 10% glycerol.
StabilityCLIC4 should be stored desiccated below -18°C. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Please prevent freeze-thaw cycles.
Amino Acid SequenceMGSSHHHHHH
SSGLVPRGSH
MALSMPLNGL
KEEDKEPLIE
LFVKAGSDGE
SIGNCPFSQR
LFMILWLKGV
VFSVTTVDLK
RKPADLQNLA
PGTHPPFITF
NSEVKTDVNK
IEEFLEEVLC
PPKYLKLSPK
HPESNTAGMD
IFAKFSAYIK
NSRPEANEAL
ERGLLKTLQK
LDEYLNSPLP
DEIDENSMED
IKFSTRKFLD
GNEMTLADCN
LLPKLHIVKV
VAKKYRNFDI
PK
PurityGreater than 95.0% as determined by SDS-PAGE.
UsageNeoScientific's products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drµgs, agricultural or pesticidal products, food additives or household chemicals.
Background

N/A

Protocol

N/A

MSDS
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