CLNS1A Human-Chloride Intracellular Channel

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CLNS1A Human

Qty


Total
$65
Catalog #
PRPS-1284
Size
Description
CLNS1A Human Recombinant produced in E. coli is a single polypeptide chain containing 261 amino acids (1-237) and having a molecular mass of 28.8kDa (molecular size on SDS-PAGE will appear higher).CLNS1A is fused to a 24 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
Additional Information
IntroductionMethylosome subunit pICln (CLNS1A), is a member of the pICln (TC 1.A.47) family. CLNS1A takes part in multiple regulatory pathways. CLNS1A interaction with Sm proteins, inhibits their compilation on U RNA and interferes with snRNP biogenesis. CLNS1A inhibits the binding of survival motor neuron protein (SMN) to Sm proteins. Methylosome subunit pICln is related with the plasma membrane where it functions as a chloride present regulator.
SynonymsCLNS1A, CLCI, ICLN, CLNS1B, Methylosome subunit pICln, Chloride channel, nucleotide sensitive 1A, Chloride conductance regulatory protein ICln, Chloride ion current inducer protein, Reticulocyte pICln.
SourceEscherichia Coli.
Physical AppearanceSterile filtered colorless solution.
FormulationThe CLNS1A solution (1mg/1ml) contains 20mM Tris-HCl buffer (pH 8.0), 0.1M NaCl, 10% glycerol and 2mM DTT.
StabilityStore at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Amino Acid SequenceMGSSHHHHHH
SSGLVPRGSH
MGSHMSFLKS
FPPPGPAEGL
LRQQPDTEAV
LNGKGLGTGT
LYIAESRLSW
LDGSGLGFSL
EYPTISLHAL
SRDRSDCLGE
HLYVMVNAKF
EEESKEPVAD
EEEEDSDDDV
EPITEFRFVP
SDKSALEAMF
TAMCECQALH
PDPEDEDSDD
YDGEEYDVEA
HEQGQGDIPT
FYTYEEGLSH
LTAEGQATLE
RLEGMLSQSV
SSQYNMAGVR
TE
PurityGreater than 90% as determined by SDS-PAGE.
UsageNeoScientific's products are furnished forLABORATORY RESEARCHUSEONLY. They may not be used as drµgs, agricultural or pesticidal products, food additives or household chemicals.
Background

N/A

Protocol

N/A

MSDS
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