CNTF Human, His-Ciliary-Neurotrophic Factor

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CNTF Human, His

Qty


Total
$65
Catalog #
CYPS-580
Size
Description
Ciliary Neurotrophic Factor Recombinant Human produced in E.Coli is a single, non-glycosylated polypeptide chain containing 220 amino acids and having a molecular mass of 25 kDa. The CNTF protein is fused to His Tag at N-terminus.The CNTF is purified by proprietary chromatographic techniques.
Additional Information
IntroductionCNTF is a polypeptide hormone whose actions appear to be restricted to the nervous system where it promotes neurotransmitter synthesis and neurite outgrowth in certain neuronal populations. The protein is a potent survival factor for neurons and oligodendrocytes and may be relevant in reducing tissue destruction during inflammatory attacks. A mutation in this gene, which results in aberrant splicing, leads to ciliary neurotrophic factor deficiency, but this phenotype is not causally related to neurologic disease. In addition to the predominant monocistronic transcript originating from this locus, the gene is also co-transcribed with the upstream ZFP91 gene. Co-transcription from the two loci results in a transcript that contains a complete coding region for the zinc finger protein but lacks a complete coding region for ciliary neurotrophic factor.CNTF is a survival factor for various neuronal cell types. Seems to prevent the degeneration of motor axons after axotomy.
SynonymsHCNTF, CNTF, Ciliary Neurotrophic Factor.
SourceEscherichia Coli.
Physical AppearanceSterile Filtered colorless clear solution at a concentration of 1mg/ml.
FormulationCNTF His tag protein solution contains 20mM Tris buffer pH-8 and 1mM DTT.
StabilityCNTF his tag fusion protein althoµgh stable 4°C for 1 week, should be stored desiccated below -18°C. Please prevent freeze-thaw cycles.
Amino Acid SequenceMGSSHHHHHH
SSGLVPRGSH
MAFTEHSPLT
PHRRDLCSRS
IWLARKIRSDLTALTESYVK
HQGLNKNINL
DSADGMPVAS
TDQWSELTEA
ERLQENLQAY
RTFHVLLARL
LEDQQVHFTP
TEGDFHQAIH
TLLLQVAAFA
YQIEELMILL
EYKIPRNEAD
GMPINVGDGG
LFEKKLWGLK
VLQELSQWTV
RSIHDLRFIS
SHQTGIPARG
SHYIANNKKM.
PurityGreater than 95.0% as determined by(a) Analysis by RP-HPLC.(b) Analysis by SDS-PAGE.
UsageNeoScientific's products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drµgs, agricultural or pesticidal products, food additives or household chemicals.
Background

N/A

Protocol

N/A

MSDS
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