Neuron-specificNeuron Specific Enolase also caled NSE is a glycolytic isoenzyme which is situated in central and peripheral neurons and neuroendocrine cells. Neuron Specific Enolase-2 is released into the CSF when neural tissue is injured. Neoplasms derived from neural or neuroendocrine tissue release Neuron Specific Enolase-2 into the blood. Neuron Specific Enolase-2 is a useful substance that has been detected in patients with certain tumors, such as neuroblastoma, small cell lung cancer, medullary thyroid cancer, carcinoid tumors, pancreatic endocrine tumors, and melanoma. ENO2 is 1 of the 3 Neuron Specific Enolase isoenzymes found in mammals. ENO2 isoenzyme, is found in mature neurons and cells of neuronal origin. An exchange from alpha Neuron Specific Enolase to gamma Neuron Specific Enolase occurs in neural tissue during development in rats and primates.
Gamma-Neuron Specific Enolase, EC 188.8.131.52, 2-phospho-D-glycerate hydro-lyase, Neural Neuron Specific Enolase, Neuron-specific Neuron Specific Enolase, NSE, Neuron Specific Enolase 2, ENO2.
Sterile Filtered clear solution.
Neuron Specific Enolase 2 is supplied in 20mM Tris pH-7.5, 0.1M KCl, 5mM MgSO4.
Store at 4°C if entire vial will be used within 1-2 weeks. Store, frozen at -20°C for longer periods of time. Please prevent freeze-thaw cycles.