FGF12 Human-Fibroblast Growth Factor

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FGF12 Human

Qty


Total
$65
Catalog #
CYPS-627
Size
Description
The FGF-12 Human recombinant protein is a single, non-glycosylated polypeptide chain produced in E. coli, having a molecular weight of 22.6kDa and containing 201 amino acids (1-181). The FGF12 is fused to a 20 amino acid His tag at the N-terminus.
Additional Information
IntroductionFGF12 is part of the Fibroblast Growth Factor (FGF) family which has a vast mitogenic and cell survival functions, and play a role in a range of biological activities, among them are embryonic development, cell growth, morphogenesis, tissue repair, tumor growth, and invasion. FGF-12 doesn’t obtain the N-terminal signal sequence present in the majority of the FGF family members, but it contains clusters of basic residues that act as a nuclear localization signal. When transfected into mammalian cells, FGF12 accumulated in the nucleus, but was not secreted. FGF12 is involved in nervous system development and function. FGF12 binds to IB2 (islet brain-2), a cellular kinase scaffold, and voltage gated sodium channels and is also involved in intracellular signaling and ion exchange.
SynonymsFGF-12, FGF12, FGF12B, FHF1, Fibroblast growth factor 12, Fibroblast growth factor homologous factor 1, FHF-1, Myocyte-activating factor.
SourceEscherichia Coli.
FormulationThe FGF-12 solution (1mg/ml) contains 20mM Tris pH-7.5, 1mM DTT, 2mM EDTA and 10% glycerol.
Amino Acid SequenceMSSHHHHHH
SSGLVPRGSH
MESKEPQLKG
IVTRLFSQQG
YFLQMHPDGT
IDGTKDENSD
YTLFNLIPVG
LRVVAIQGVK
ASLYVAMNGE
YLYSSDVFT
PECKFKESVF
ENYYVIYSST
LYRQQESGRA
WFLGLNKEGQ
IMKGNRVKKT
KPSSHFVPKP
IEVCMYREQS
LHEIGEKQGR
RKSSGTPTM
NGGKVVNQDS
T.
PurityGreater than 90% as determined by SDS-PAGE.
UsageNeoScientific's products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drµgs, agricultural or pesticidal products, food additives or household chemicals.
StorageStore FGF12 at -20°C. Can be stored at 4°C for a limited period of time of 7 days.
Background

N/A

Protocol

N/A

MSDS
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