Frizzled-1 Human Recombinant produced in HEK293 cells, corresponding to the extracellular region of mature Human Frizzled-1 (amino acids 112-228) and fused to the Fc region of Human IgG1, having an MW of 46kDa. Frizzled-1 is purified by proprietary chromatographic techniques.
“Frizzled” gene family members encode 7-transmembrane domain proteins which are receptors for Wnt signaling proteins. The FZD1 protein includes a signal peptide, a cysteine-rich domain in the N-terminal extracellular region, 7 transmembrane domains, and a C-terminal PDZ domain-binding motif. The FZD1 transcript is expressed in the adult heart, placenta, lung, kidney, pancreas, prostate, and ovary and in the fetal lung and kidney.
Sterile Filtered White lyophilized (freeze-dried) powder.
The protein was lyophilized without any additives.
It is recommended to reconstitute the lyophilized FZD1 in sterile 1xPBS not less than 100
Lyophilized FZD1 althoµgh stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution FZD1 should be stored at 4°C between 2-7 days and for future use below -18°C.For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Please prevent freeze-thaw cycles.