GHBP Bovine-Growth Hormone

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GHBP Bovine

Qty


Total
$65
Catalog #
CYPS-478
Size
Description
Growth Hormone Binding Protein Bovine Recombinant produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 237 amino acids and having a molecular mass of 28 kDa. GHBP Bovine is purified by proprietary chromatographic techniques.
Additional Information
IntroductionGHBP is a transmembrane receptor for growth hormone. Binding of growth hormone to the receptor leads to receptor dimerization and the activation of an intra- and intercellular signal transduction pathway leading to growth. A common alternate allele of this gene, called GHRd3, lacks exon three and has been well-characterized. Mutations in this gene have been associated with Laron syndrome, also known as the growth hormone insensitivity syndrome (GHIS), a disorder characterized by short stature. Other splice variants, including one encoding a soluble form of the protein (GHRtr), have been observed but have not been thoroµghly characterized.
SynonymsGHR, GHBP, GH receptor, Somatotropin receptor.
SourceEscherichia Coli.
Physical AppearanceSterile Filtered White lyophilized (freeze-dried) powder.
FormulationThe Growth Hormone Binding Protein Bovine was lyophilized from a concentrated (1mg/ml) solution with 0.0045mM NaHCO3.
SolubilityIt is recommended to reconstitute the lyophilized GHBP Bovine in sterile 18MΩ-cm H2O not less than 100µg/ml, which can then be further diluted to other aqueous solutions.
StabilityLyophilized Growth Hormone Binding Protein Bovine althoµgh stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution GHBP Bovine should be stored at 4°C between 2-7 days and for future use below -18°C.For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Please prevent freeze-thaw cycles.
Amino Acid SequenceThe
sequence
of
the
first
five
N-terminal
amino
acids
was
determined
and
was
found
to
be
Ala-Phe-Ser-Gly-Ser.
PurityGreater than 95.0% as determined by:(a) Analysis by SEC-HPLC.(b) Analysis by SDS-PAGE.
UsageNeoScientific's products are furnished for LABORATORY RESEARCH USE ONLY.They may not be used as drµgs,agricultural or pesticidal products, food additives or household chemicals.
Background

N/A

Protocol

N/A

MSDS
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