GUCA2B Human-Other

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GUCA2B Human


Catalog #
Prouroguanylin Human Recombinant is 10 kDa protein containing 88 amino acid residues of the human prouroguanylin and 2 additional amino acid residues.GPVYIQYQGF RVQLESMKKL SDLEAQWAPS PRLQAQSLLP AVCHHPALPQ DLQPVCASQE ASSIFKTLRT IANDDCELCV NVACTGCLThe Prouroguanylin is purified by proprietary chromatographic techniques.
Additional Information
IntroductionProuroguanylin is a 112-amino-acid prohormone precursor of uroguanylin- mature biologically active 16-amino-acid peptide cleaved from its C-terminus. Guanylin binds to receptor-guanylate cyclases (CG-C) resulting in increased intracellular cGMP levels leading to CFTCR (Cystic Fibrosis Transmembrane Conductance Regulator) activation and subsequent rise in fluid and electrolyte secretion into the lumen.Prouroguanyline knock-out mice showed impaired renal excretion of external NaCl leading to elevated blood pressure independent of the level of diatary salt intake.Prouroguanylin is the predominant circulating molecular form found in circulation and in biological fluids.
SynonymsGuanylate cyclase activator 2B, UGN, GCAP-II, GUCA2B.
SourceEscherichia Coli.
Physical AppearanceSterile Filtered White lyophilized (freeze-dried) powder.
FormulationSterile filtered and lyophilized from 0.5 mg/ml in 50mM Phosphate buffer pH-7.4.
SolubilityAdd 0.2 ml of deionized H2O and let the lyophilized pellet dissolve completely.
StabilityStore lyophilized protein at -20°C. Aliquot the product after reconstitution to avoid repeated thaw-freeze cycles and store at -80°C. Reconstituted protein can be stored at 4°C for a limited period of time.
PurityGreater than 95.0% as determined by(a) Analysis by RP-HPLC.(b) Analysis by SDS-PAGE.
UsageNeoScientific's products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drµgs, agricultural or pesticidal products, food additives or household chemicals.
Purification MethodThree-step procedure using IMAC and size exclusion chromatography before and after refolding.
SpecificityThe recombinant sequence is 100% homologous to the native human sequence.




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