HCV NS3 Genotype-1b-Hepatitis C

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HCV NS3 Genotype-1b

Qty


Total
$195
Catalog #
HCPS-254
Size
Description
The E.coli derived recombinant protein contains the HCV NS3 immunodominant regions, amino acids 1192-1459. The protein is fused to a GST tag at N-Terminus.
Additional Information
IntroductionHCV is a small 50nm, enveloped, single-stranded, positive sense RNA virus in the family Flaviviridae. HCV has a high rate of replication with approximately one trillion particles produced each day in an infected individual. Due to lack of proofreading by the HCV RNA polymerase, the HCV has an exceptionally high mutation rate, a factor that may help it elude the host's immune response. Hepatitis C virus is classified into six genotypes(1-6) with several subtypes within each genotype. The preponderance and distribution of HCV genotypes varies globally. Genotype is clinically important in determining potential response to interferon-based therapy and the required duration of such therapy. Genotypes 1 and 4 are less responsive to interferon-based treatment than are the other genotypes (2, 3, 5 and 6).
SynonymsNULL
SourceNULL
Formulation1.5M urea, 25mM Tris-HCl pH-8, 0.2% Triton-X & 50% Glycerol.
PurityHCV NS3 Genotype-1b protein is >95% pure as determined by 10% PAGE (coomassie staining).
UsageNeoScientific's products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drµgs, agricultural or pesticidal products, food additives or household chemicals.
ApplicationsELISA, Western blots and Flow-throµgh.
StorageNS3 Genotype-1b althoµgh stable at 4°C for 1 week, should be stored below -18°C. Please prevent freeze thaw cycles.
Purification MethodHCV NS3 Genotype-1b protein was purified by proprietary chromatographic technique.
SpecificityImmunoreactive with sera of HCV-infected individuals.
Background

N/A

Protocol

N/A

MSDS
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